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CaMKII, a member of the calcium / calmodulin-activated protein kinas family, functions in neural synapatic stimulation and T-cell receptor signaling. CaMKII is expressed in many tissues, but it is specifically found in the neurons of the forebrain, and its mRNA is found within the dendrites and the soma of the neuron. CaMKII in neurons consists of two subunits of 52 (alpha genes) and 60 kDa (beta genes). CaMKII has catalytic and regulatory domains as well as an ATP-binding domain and a consensus phosphorylation site. Binding of calcium / calmodulin to its regulatory domain releases its auto- inhibitory effect and activates the kinase. This kinase activation results in autophosphorylation at threonine 286. Autophosphorylation confers enhanced affinity of CaMKII for NMDA receptors in postsynaptic densities.
- Product categories: Antibody Products>Neuroscience and Signal Transduction Antibodies|Products - Pkg Size: 100 µg - Clone: 6G9 - Target: CaMKII - Research Area: Neuroscience - Applications: ELISA, ICC, IF, IHC, IP, WB, RIA - Concentration: Lot Specific - Formulation: PBS, pH 7.4. - Storage and Stability: This antibody is stable for at least one (1) year at -20°C. Avoid repeated freezing and thawing.
Suggested application(s)ELISA, Immunocytochemistry, Immunofluorescence and cell labelling, Immunohistochemistry (IHC), Immunoprecipitation, Western blot and immunodetection, RadioImmunoassays (RIA)